Toxic Entanglements utilizes architecture as a vehicle for the articulation of existing alternative waste treatment processes tying space, funding, and actors of various scales in order to enable its implementation. Matter and resources are exchanged, produced, consumed, and expelled. What is toxic for certain species nurtures the next, through a continuous circular system. An assemblage of 10 processes that function in unison regulating and providing for each other. An infrastructure that arranges ecosystems through biological and mechanical processes that circulates matter in various states of transformation. We analyze existing environments that are tied to waste management today to envision a different New York. 50 Hudson Yards was chosen for the implementation of this first prototype due both to location at the interstice of unsustainable waste infrastructure, toxic sites, and problematic relations to animals, and as an effort to reground the East Yards, in an equitable sustainable future for New York.